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Description
(visit source) Gerster H
After 10 to 15 years of disease, this pattern progresses in up to 50% of untreated patients, during which time clinical symptoms slowly lead to progressive deterioration over a period of many years, a stage of disease defined as secondary progressive MS (SPMS)
Acute VPA overdose Although acute overdoses of VPA usually present as mild alteration in consciousness, large overdoses can be lifethreatening
The mean dose during the treatment phase was 1,087 mg/day resulting in a mean trough total valproate level of 72.5 mcg/mL, with a range of 31 to 133 mcg/mL
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