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Wright JW, Kawas LH, Harding JW. The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. Prog Neurobiol. 2015 Feb;125:26-46. doi: 10.1016/j.pneurobio.2014.11.004. Review. PubMed PMID: 25455861

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Loading Phase (Weeks 1 to 6) Goal: Introduce the peptide, check for tolerance, begin biological activity Dose: 1 to 2 mg, two times a week Track: Photos, notes, how the patient feels Transition Phase (Weeks 7 to 12) Goal: See what is working, adjust if needed Dose: Stay where you are or drop to once a week if progress stalls Ask: What feels better

The lung was then inflated using a compressed air source attached to an underwater seal to slowly increase transpulmonary pressure (PL) from 0 to 30 cmH 2 O

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