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For instance, a randomized controlled phase I/II clinical trial of tivantinib combined with irinotecan and cetuximab showed no significant improvement of PFS or OS in metastatic CRC patients with wild-type KRAS (Rimassa et al., 2019)
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However, this approach alone cannot prevent subsequent reperfusion injury 32
Plus, they promote success in meeting all of the patients recovery goals, not just eliminating drug use
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