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Collectively, these results directly demonstrate that resistance-causing PfK13 mutations in early rings result in a 1.5-fold loss in PfK13 protein abundance, which decreases intra-parasitic heme levels and subsequently impairs peroxide antimalarial activation
Buzzaccarini G, Marin L, Noventa M, et al
NRF2 plays a critical role in this process by upregulating the expression of genes involved in the synthesis of -GC, thereby increasing the overall production of GSH [34]
A.da SilvaF
SWFI (Sterile Water for Injection) SWFI is a specific grade of sterile, preservative-free water
