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Its concentration in plasma declines significantly with age from approximately 200 ng/mL at age 20 to roughly 80 ng/mL by age 60

A number of neurotransmitter or metabolic pathways contribute to the nervous system disorder known as depression

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Moreover, TDNPs have been verified to activate the Nrf2/HO-1 signaling pathway to promote the proliferation and migration of fibroblasts by improving their endogenous antioxidant capacity and reducing cell apoptosis [40]

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